PARP inhibition protects mitochondria and reduces ROS production
![](https://ars.els-cdn.com/content/image/1-s2.0-S0891584917302216-gr2.jpg)
Mitochondrial Network Determines Intracellular ROS Dynamics and
![](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs12276-022-00894-x/MediaObjects/12276_2022_894_Fig1_HTML.png)
Mitochondrial PARP1 regulates NAD+-dependent poly ADP-ribosylation of mitochondrial nucleoids
![](https://www.frontiersin.org/files/Articles/1243613/fphar-14-1243613-HTML-r1/image_m/fphar-14-1243613-g001.jpg)
Frontiers The mechanisms of action of mitochondrial targeting
![](https://static.hindawi.com/articles/omcl/volume-2021/7308897/figures/7308897.fig.006d.jpg)
Olaparib: A Clinically Applied PARP Inhibitor Protects from
![](https://www.frontiersin.org/api/v3/articles/_ipx/w_410,f_jpg/https://www.frontiersin.org/files/Articles/450637/fphys-10-00538-HTML/image_m/fphys-10-00538-g007.jpg)
Frontiers PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells
![](https://ars.els-cdn.com/content/image/1-s2.0-S0891584917302216-gr2.jpg)
PARP inhibition protects mitochondria and reduces ROS production
![](https://www.biorxiv.org/content/biorxiv/early/2022/02/13/2021.07.30.454548/F7.large.jpg)
Early loss of endogenous NAD+ following rotenone treatment leads
![](https://www.science.org/cms/10.1126/scisignal.2000902/asset/161042ab-9b0d-4d02-99f2-bd5efc112e5c/assets/graphic/4_ra20_f8.jpeg)
Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is
![](https://www.researchgate.net/profile/Kazunari-Kondo/publication/41532462/figure/fig1/AS:667205377212432@1536085566649/ERK1-2-phosphorylation-PARP-1-and-caspase-3-activation-induced-by-ESA-A-Western-blot.png)
ERK1/2 phosphorylation, PARP-1, and caspase-3 activation induced
![](https://ars.els-cdn.com/content/image/1-s2.0-S000629521830426X-gr3.jpg)
PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome - ScienceDirect
![](https://www.biorxiv.org/content/biorxiv/early/2022/02/13/2021.07.30.454548/F3.large.jpg)
Early loss of endogenous NAD+ following rotenone treatment leads to Sarm1 activation that is ameliorated by PARP inhibition